Lab members are highlighted in bold.
2024
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/11/13048_2024_1555_Fig1_HTML.webp)
Searching for the ‘X’ factor: investigating the genetics of primary ovarian insufficiency
Anya Knight; Sara Sugin; Andrea Jurisicova
Journal of Ovarian Research
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/12/annotated_ari_hm_l.png)
metasnf: Meta Clustering with Similarity Network Fusion in R
Prashanth S. Velayudhan; Xiaoqiao Xu; Prajkta Kallurkar; Ana Patricia Balbon; Maria T. Secara; Adam Taback; Denise Sabac; Nicholas Chan; Shihao Ma; Bo Wang; Daniel Felsky; Stephanie H Ameis; Brian Cox; Colin Hawco; Lauren Erdman; Anne L. Wheeler
arXiv
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/12/F2.large_-1024x816.jpg)
Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures
Morgan Zych; Natalie Lo; Kate A. Patton; Kewei Wang; Brian J. Cox
bioRxiv
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/12/F3.large_-1-1024x819.jpg)
Genetic co-occurrence networks identify polymorphisms within ontologies highly associated with preeclampsia
Andreea Obersterescu; Brian J. Cox
medRxiv
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/gr1.jpg)
The Placenta Pathology Tool: an online application for understanding histopathologic lesions
Rini Lukose; Maria Mazaharally; Raymond W. Redline; Brian J. Cox
American Journal of Obstetrics and Gynecology
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/11/41592_2024_2493_Fig4_HTML.webp)
A comprehensive human embryo reference tool using single-cell RNA-sequencing data
Cheng Zhao; Alvaro Plaza Reyes; John Paul Schell; Jere Weltner; Nicolás M. Ortega; Yi Zheng; Åsa K. Björklund; Laura Baqué-Vidal; Joonas Sokka, Ras Torokovic; Brian Cox; Janet Rossant; Jianping Fu; Sophie Petropoulos; Fredrik Lanner
Nature Methods
2023
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/1-s2.0-S0142961223002636-gr1.jpg)
Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation
Marianne Wauchop; Naimeh Rafatian; Yimu Zhao; Wenliang Chen; Mark Gagliardi; Stéphane Massé; Brian J. Cox; Patrick Lai; Timothy Liang; Shira Landau et al.
Biomaterials
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/m_btad523f1.jpeg)
metGWAS 1.0: an R workflow for network-driven over-representation analysis between independent metabolomic and meta-genome-wide association studies
Saifur R Khan; Andreea Obersterescu; Erica P Gunderson; Babak Razani; Michael B Wheeler; Brian J Cox
Bioinformatics
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/gr1-1.jpg)
Proinflammatory changes in the maternal circulation, maternal–fetal interface, and placental transcriptome in preterm birth
Camille Couture; Marie-Eve Brien; Ines Boufaied; Cyntia Duval; Dorothee Dal Soglio; Elizabeth Ann L Enninga; Brian Cox; Sylvie Girard
American Journal of Obstetrics and Gynecology
2022
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/Screenshot-2024-07-18-at-3.13.48 PM-696x1024.png)
Here and there a trophoblast, a transcriptional evaluation of trophoblast cell models
Brian J. Cox; Kendra Naismith
Cellular and Molecular Life Sciences
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/jcm-11-04185-g003.jpg)
Maternal Immune Cell and Cytokine Profiles to Predict Cardiovascular Risk Six Months after Preeclampsia
Malia S Q Murphy; Samantha J Benton; Brian Cox; Kara Nerenberg; Scott McComb; Lakshmi Krishnan; Risini D Weeratna; Jean-François Paré; Alysha L J Dingwall-Harvey; Shannon A Bainbridge; Andrée Gruslin; Laura M Gaudet
Journal of Clinical Medicine
DOI: 10.3390/jcm11144185
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/gr1-2.jpg)
The amnion as a window into human pluripotency
Brian J Cox; Amy Ralston
Cell Stem Cell
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/1-s2.0-S014340042200073X-gr1.jpg)
Computational analysis identified accelerated senescence as a significant contribution to preeclampsia pathophysiology
Nadia Siddique; Brian Cox
Placenta
![](https://coxsystemsbiology.medicine.utoronto.ca/wp-content/uploads/2024/07/lax_75061_elife-75061-fig2-v3.tif-1024x677.webp)
The need for more research into reproductive health and disease
Natalie D Mercuri; Brian J Cox
eLife
DOI: 10.7554/eLife.75061
Last updated: 12/2024