People

Brian Cox

Principal Investigator

Training:

In my research, I am intrigued that many chronic health issues may have origins in the womb or early in development. Moreover, while placental dysfunctions of various etiologies affect 5-10% of all pregnancies, there are few diagnostic markers and treatment options. I founded the lab to work on this area because there are a large number of women and babies out there who need better healthcare. The understudied complexities of pregnancy disorders could benefit from new hypotheses and a different technical approach.

Ana Patricia Balbon

Research Associate

I’m a bioinformatician in the Cox Systems Biology lab where I build statistical models from clinical and genomic data. In my opinion, developmental biology is one of the most beautiful branches of biology — it is a joy to marvel at the order within its complex interactions. Prior to pivoting to computational biology, I was a researcher in science communication and studied the social context of science and technology. In my spare time, I like to train for 5K races and take ballet classes! ✨

Ebenezer Brefo-Appiah

Graduate Student

My research focuses on training artificial neural networks using various types of data, such as macroscopic data, histopathology data, clinical data, genetic data, and current literature, to advance the field of reproductive biology and improve pregnancy outcomes. Currently, my research interest lies in the applications of computer vision and natural language processing to address preeclampsia, a poorly understood disorder. Looking ahead, a future where AI technologies revolutionize maternal and fetal medicine awaits.

Alexis Ejeckam

Graduate Student

Nadia Siddique

Graduate Student

Co-advised by Dr. Andrea Jurisicova

Sara Sugin

Graduate Student

Co-advised by Dr. Andrea Jurisicova

I am a PhD student studying the different types of microRNAs expressed in trophoblast cells and the role they play in ensuring proper placentation and maternal immune tolerance of the growing fetus. My work is done both on mouse cell lines and whole-animal models of a trophoblast-specific microRNA deletion. I started off my research career in biological physics and mathematics, having done field work in Civil and Mineral Engineering, but have quickly discovered that my passions lay within developmental biology. Outside of the lab, I am an avid reader, photographer, concert-goer, and sport enthusiast.

Morgan Zych

Graduate Student

Morgan is a PhD student in the Cox Lab. Her research interests include advanced cell culture constructs and developmental immunology. Morgan’s previous work in a tumor immunotherapy laboratory left her well-poised to study the crosstalk between trophoblast and the maternal immune system. She has now created a culture system which represents human column cytotrophoblast development and crosstalk with decidual natural killer cells in vitro. She would love to talk with you about ways this culture system could be adapted to model disorders of pregnancy, or hear any other ideas you have about these cultures! Morgan also enjoys playing the drums and hanging out with her cat, who is named Soup.

Maslin Blundell

Undergraduate Student

I am a 2nd year Physiology Specialist with great enthusiasm for understanding the placenta and how placental dysfunction results in disorders of pregnancy!  I work mainly on a bioinformatics project studying the connection between placental development and cancer using scRNA-seq data.  I also support wet lab projects involving cell culture, qPCR, Western blotting, and more.  When not in the lab, I am playing trumpet with my siblings!

Genlei Lu

Undergraduate Student

I am a 3rd year Immunology student interested in reproductive immunology. Currently, my work aims to examine the immune milieu at the murine feto-maternal interface primarily using flow cytometry, immunohistochemistry, and fluorescence microscopy; I also maintain cultures of human placental organoids (my children) semi-regularly. Before starting at the University of Toronto, I completed a diploma in IT administration. In my spare time, I’ve been learning to make Japanese mud balls (Dorodango).

Postgraduate
NameRoleYearThesis/Project TitleCurrent
Zi Qi (Jessica) LinMSc2022-2024Assessment of a murine model of maternal cardiovascular remodeling in pregnancyMD Candidate at Western University
Sachin MatadeenMHSc Project Student2024
Pascale CharettePostdoctoral Fellow2020-2024Programs Officer at Canada Foundation for Innovation
Andreea ObsterescuMSc2019-2022Network modeling of correlating minor alleles enriched to human phenotypesBioinformatics Specialist at Sinai Health
Jessica WeltonMSc2020-2022Role of histone deacetylases in early embryo cell fate, in vivo and in vitro modelsPhD Candidate at University of Toronto
Arnold HuangMHSc Project Student2021Time to event modeling of adverse pregnancy eventsBusiness Intelligence Analyst at Easy Group Inc
Rini LukoseMHSc Project Student2021Development of R Shiny Apps for biomedical research Intern at Roche
Maria MazaharallyMHSc Project Student2021Development of R Shiny app for biomedical research Research Analyst at CAMH
Ursula NosiPostdoctoral Fellow
PhD
2012-2021Characterization of the role of microRNAs in trophoblast stem cell specificationProcess and Development Scientist at BlueRock
Brian ParkMSc2017-2020Subcellular dynamics of RNAs and microRNAs in mouse ESCs and TSCsSenior Data Scientist at Bold Therapeutics
Frances WongPhD2013-2019Cellular systems biology of human placentationAssistant Professor at Toronto Metropolitan University
Katherine LeaveyPostdoctoral Fellow
PhD
2013-2018Identification of molecular subtypes of preeclampsia via large scale microarray analysisResearch Coordinator at McMaster University
Jodie OdameMSc2012-2014Molecular function of heparin as a therapy for preeclampsiaHemotology/Oncology Resident at Hospital for Sick Children
Undergraduate
NameRoleYearProject Title
Nataliia Hrytskiv2024
Natalie Faraj2024
Subaita RahmanHMB4982024Transcriptional comparison of maternal hearts from normal and pseudopregnancy
Natalie LoPSL3992024Histological assessment of human placental organoids with and without IL8 exposure
Kate PattonPSL3992024Histological assessment of human placental organoids with and without uNK cells
Genlei LuVolunteer2024Flowcytometric analysis of immune cell populations in mouse decidua from normal and pseudopregnancy
MingZheng LiuCSB4982023Modeling genomic polymorphism data using cooccurrence
Jingzhi LiuPSL4982023Immunohistology assessment of mouse decidua from normal and pseudopregnancy
Genlei LuPSL2992023Flowcytometric analysis of immune cell populations in mouse decidua from normal and pseudopregnancy
Dorothy WangPSL2992023Histological assessment of human placental organoids with and without uNK cells
Adam TabackSummer student2023Clustering of clinical data of preeclampsia patients
Jingzhi LiuSummer student2022Immunohistology assessment of mouse decidua from normal and pseudopregnancy
Zoe McManusAMGEN Scholar2021Clustering of clinical data of preeclampsia patients
Nadia SiddiquePSL4982021Role of cellular senescence in subtypes of preeclampsia
Kendra NaismithSummer student2021Meta-analysis of gene expression data for induced human trophoblast cells
Zi Qi (Jessica) LinPSL4982020Maternal cardiac remodelling in mouse models
Nadia SiddiqueVolunteer2020Role of cellular senescence in subtypes of preeclampsia
Kendra NaismithSummer student2020Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast
Katie CheahSummer student2020Identification of RNA sequence polymorphisms in preeclampsia
Abdul ArifVolunteer2020Novel clustering methods for single cell RNA-seq
Zafina BudhwaniAMGEN Scholar2019Generation of murine blastoids
Linda GuoAMGEN Scholar2019Assessment of loss of function of the SFMBT2 imprinted microRNA cluster on expression of repetitive viral elements
Kendra NaismithPSL4982019Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast
Andreea ObersterescuSummer student2019Modeling genomic polymorphism data using cooccurrence
Megan KatesSummer student2018Immunobiological assessment of the stem cell niche in human placenta
Kendra NaismithSummer student2018Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast
Andreea ObsterescuPSL4982018Modeling genomic polymorphism data using cooccurrence
Isaac GibbsSummer student2017Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction
Isaac GibbsSummer student2016Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction
Isaac GibbsSummer student2015Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction
Tsu Joey HuangHMB4982014Construction of inducible microRNA vectors
Robert MiceliSummer student2014Construction of a trophoblast cell fate reporter transgene
Alex MagonySummer student2014Nuclear and cytoplasmic fractionation for RNA and proteins
David YangPSL4982013Nuclear and cytoplasmic fractionation for RNA and proteins
Robert MiceliSummer student2012Construction of a trophoblast cell fate reporter transgene
Ivy LinSummer student2012Optimization of isolation of human trophoblast cells from first trimester placenta
David YangSummer student2012Generation of inducible transcription factor vectors for trophoblast cell fate

Last updated: 09/2024