
Brian Cox
Principal Investigator
Affiliations:
Associate Professor, Department of Physiology
Tier II Canada Research Chair in Placental Development and Maternal-Fetal Health (2017-2022)
Training:
Postdoctoral Fellow Hospital for Sick Children
PhD Molecular and Medical Genetics, University of Toronto
MSc Applied Biochemistry, University of Guelph
BSc Environmental Biochemistry, University of Guelph
In my research, I am intrigued that many chronic health issues may have origins in the womb or early in development. Moreover, while placental dysfunctions of various etiologies affect 5-10% of all pregnancies, there are few diagnostic markers and treatment options. I founded the lab to work on this area because there are a large number of women and babies out there who need better healthcare. The understudied complexities of pregnancy disorders could benefit from new hypotheses and a different technical approach.
Team

Ana Patricia Balbon
Research Associate
I’m a bioinformatician in the Cox Systems Biology lab where I build statistical models from clinical and genomic data. In my opinion, developmental biology is one of the most beautiful branches of biology — it is a joy to marvel at the order within its complex interactions. Prior to pivoting to computational biology, I was a researcher in science communication and studied the social context of science and technology. Outside of the lab, I am either training for my next race or learning a new language on Duolingo!

Ebenezer Brefo-Appiah
Graduate Student
My research focuses on training artificial neural networks using various types of data, such as macroscopic data, histopathology data, clinical data, genetic data, and current literature, to advance the field of reproductive biology and improve pregnancy outcomes. Currently, my research interest lies in the applications of computer vision and natural language processing to address preeclampsia, a poorly understood disorder. Looking ahead, a future where AI technologies revolutionize maternal and fetal medicine awaits.

Alexis Ejeckam
Graduate Student
I am a first year student doing my PhD in Physiology. My project involves investigating imprinted microRNAs in the placenta and their role in immunological tolerance of the semi-allogenic fetus. In my free time, I like to do Muay Thai and bake muffins!

Nadia Siddique
Graduate Student
Co-advised by Dr. Andrea Jurisicova

Sara Sugin
Graduate Student
Co-advised by Dr. Andrea Jurisicova
I am a PhD student studying the different types of microRNAs expressed in trophoblast cells and the role they play in ensuring proper placentation and maternal immune tolerance of the growing fetus. My work is done both on mouse cell lines and whole-animal models of a trophoblast-specific microRNA deletion. I started off my research career in biological physics and mathematics, having done field work in Civil and Mineral Engineering, but have quickly discovered that my passions lay within developmental biology. Outside of the lab, I am an avid reader, photographer, concert-goer, and sport enthusiast.

Morgan Zych
Graduate Student
Morgan is a PhD student in the Cox Lab. Her research interests include advanced cell culture constructs and developmental immunology. Morgan’s previous work in a tumor immunotherapy laboratory left her well-poised to study the crosstalk between trophoblast and the maternal immune system. She has now created a culture system which represents human column cytotrophoblast development and crosstalk with decidual natural killer cells in vitro. She would love to talk with you about ways this culture system could be adapted to model disorders of pregnancy, or hear any other ideas you have about these cultures! Morgan also enjoys playing the drums and hanging out with her cat, who is named Soup.

Maslin Blundell
Undergraduate Student
I am a 2nd year Physiology Specialist with great enthusiasm for understanding the placenta and how placental dysfunction results in disorders of pregnancy! I work mainly on a bioinformatics project studying the connection between placental development and cancer using scRNA-seq data. I also support wet lab projects involving cell culture, qPCR, Western blotting, and more. When not in the lab, I am playing trumpet with my siblings!

Genlei Lu
Undergraduate Student
I am a 3rd year Immunology student interested in reproductive immunology. Currently, my work aims to examine the immune milieu at the murine feto-maternal interface primarily using flow cytometry, immunohistochemistry, and fluorescence microscopy; I also maintain cultures of human placental organoids (my children) semi-regularly. Before starting at the University of Toronto, I completed a diploma in IT administration. In my spare time, I’ve been learning to make Japanese mud balls (Dorodango).

Hamza Mahmood
Undergraduate Student
I am a 3rd-year Electrical Engineering student interested in machine learning, electronics, and biology. I am currently working on a few bioinformatics projects. Outside the lab, I enjoy MMA, reading, and adventure sports.

Kate Patton
Undergraduate Student
I’m a 4th year physiology student with a passion for in vitro systems of placental development and maternal-fetal immune interactions. Currently, my project is exploring the effects of co-culture between decidual natural killer cells and trophoblast organoids. In my free time I enjoy reading, drawing, and playing with my cat Luna!
Alumni
Postgraduate
Name | Role | Year | Thesis/Project Title | Current | |
Zi Qi (Jessica) Lin | MSc | 2022-2024 | MD Candidate at Western University | ||
Sachin Matadeen | MHSc Project Student | 2024 | PhD Candidate at University of Toronto | ||
Pascale Charette | Postdoctoral Fellow | 2020-2024 | Programs Officer at Canada Foundation for Innovation | ||
Andreea Obsterescu | MSc | 2019-2022 | Network modeling of correlating minor alleles enriched to human phenotypes | Bioinformatics Specialist at Sinai Health | |
Jessica Welton | MSc | 2020-2022 | Role of histone deacetylases in early embryo cell fate, in vivo and in vitro models | PhD Candidate at University of Toronto | |
Arnold Huang | MHSc Project Student | 2021 | Time to event modeling of adverse pregnancy events | Business Intelligence Analyst at Easy Group Inc | |
Rini Lukose | MHSc Project Student | 2021 | Development of R Shiny Apps for biomedical research | Intern at Roche | |
Maria Mazaharally | MHSc Project Student | 2021 | Development of R Shiny app for biomedical research | Research Analyst at CAMH | |
Ursula Nosi | Postdoctoral Fellow PhD | 2012-2021 | Characterization of the role of microRNAs in trophoblast stem cell specification | Process and Development Scientist at BlueRock | |
Brian Park | MSc | 2017-2020 | Subcellular dynamics of RNAs and microRNAs in mouse ESCs and TSCs | Senior Data Scientist at Bold Therapeutics | |
Frances Wong | PhD | 2013-2019 | Cellular systems biology of human placentation | Assistant Professor at Toronto Metropolitan University | |
Katherine Leavey | Postdoctoral Fellow PhD | 2013-2018 | Identification of molecular subtypes of preeclampsia via large scale microarray analysis | Research Coordinator at McMaster University | |
Jodie Odame | MSc | 2012-2014 | Molecular function of heparin as a therapy for preeclampsia | Hemotology/Oncology Resident at Hospital for Sick Children |
Undergraduate
Name | Role | Year | Project Title |
Nataliia Hrytskiv | 2024 | ||
Natalie Faraj | 2024 | ||
Subaita Rahman | HMB498 | 2024 | Transcriptional comparison of maternal hearts from normal and pseudopregnancy |
Natalie Lo | PSL399 | 2024 | Histological assessment of human placental organoids with and without IL8 exposure |
Kate Patton | PSL399 | 2024 | Histological assessment of human placental organoids with and without uNK cells |
Genlei Lu | Volunteer | 2024 | Flowcytometric analysis of immune cell populations in mouse decidua from normal and pseudopregnancy |
MingZheng Liu | CSB498 | 2023 | Modeling genomic polymorphism data using cooccurrence |
Jingzhi Liu | PSL498 | 2023 | Immunohistology assessment of mouse decidua from normal and pseudopregnancy |
Genlei Lu | PSL299 | 2023 | Flowcytometric analysis of immune cell populations in mouse decidua from normal and pseudopregnancy |
Kewei (Dorothy) Wang | PSL299 | 2023 | Histological assessment of human placental organoids with and without uNK cells |
Adam Taback | Summer student | 2023 | Clustering of clinical data of preeclampsia patients |
Jingzhi Liu | Summer student | 2022 | Immunohistology assessment of mouse decidua from normal and pseudopregnancy |
Zoe McManus | AMGEN Scholar | 2021 | Clustering of clinical data of preeclampsia patients |
Nadia Siddique | PSL498 | 2021 | Role of cellular senescence in subtypes of preeclampsia |
Kendra Naismith | Summer student | 2021 | Meta-analysis of gene expression data for induced human trophoblast cells |
Zi Qi (Jessica) Lin | PSL498 | 2020 | Maternal cardiac remodelling in mouse models |
Nadia Siddique | Volunteer | 2020 | Role of cellular senescence in subtypes of preeclampsia |
Kendra Naismith | Summer student | 2020 | Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast |
Katie Cheah | Summer student | 2020 | Identification of RNA sequence polymorphisms in preeclampsia |
Abdul Arif | Volunteer | 2020 | Novel clustering methods for single cell RNA-seq |
Zafina Budhwani | AMGEN Scholar | 2019 | Generation of murine blastoids |
Linda Guo | AMGEN Scholar | 2019 | Assessment of loss of function of the SFMBT2 imprinted microRNA cluster on expression of repetitive viral elements |
Kendra Naismith | PSL498 | 2019 | Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast |
Andreea Obersterescu | Summer student | 2019 | Modeling genomic polymorphism data using cooccurrence |
Megan Kates | Summer student | 2018 | Immunobiological assessment of the stem cell niche in human placenta |
Kendra Naismith | Summer student | 2018 | Generation of an experimentally informed collection of gene sets related to human placenta and trophoblast |
Andreea Obsterescu | PSL498 | 2018 | Modeling genomic polymorphism data using cooccurrence |
Isaac Gibbs | Summer student | 2017 | Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction |
Isaac Gibbs | Summer student | 2016 | Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction |
Isaac Gibbs | Summer student | 2015 | Transcriptional comparison of hypertensive and normotensive placenta with fetal growth restriction |
Tsu Joey Huang | HMB498 | 2014 | Construction of inducible microRNA vectors |
Robert Miceli | Summer student | 2014 | Construction of a trophoblast cell fate reporter transgene |
Alex Magony | Summer student | 2014 | Nuclear and cytoplasmic fractionation for RNA and proteins |
David Yang | PSL498 | 2013 | Nuclear and cytoplasmic fractionation for RNA and proteins |
Robert Miceli | Summer student | 2012 | Construction of a trophoblast cell fate reporter transgene |
Ivy Lin | Summer student | 2012 | Optimization of isolation of human trophoblast cells from first trimester placenta |
David Yang | Summer student | 2012 | Generation of inducible transcription factor vectors for trophoblast cell fate |
Day in the life!





Last updated: 03/2025